Augmented cerebellar lactate in copper deficient rat pups originates from both blood and cerebellum

[1-C]lactate signal derived from hyperpolarized [1-C]pyruvate originates from the brain, not from the blood

Introduction Injection of hyperpolarized [1-C]pyruvate and detection of metabolic products such as [1-C]lactate is a promising new technique for the study of metabolism in vivo in healthy and pathologic conditions, such as tumors [1]. Recently, we have shown detection of [1-C]lactate in the normal brain in vivo after injection of hyperpolarized [1-C]pyruvate [2]. However, the spatial origin of ...

Actions and release characteristics of secretin in the rat cerebellum

Secretin, a peptide hormone of the gastrointestinal system, has been implicated in the etiology of autism. Our laboratory previously demonstrated the expression of secretin and its receptors in specific central neurons, and found for the first time that secretin is neuroactive in the cerebellum. We showed that bath application of secretin facilitated the release of GABA from terminals of basket...

Actions and release characteristics of secretin in the rat cerebellum

Secretin, a peptide hormone of the gastrointestinal system, has been implicated in the etiology of autism. Our laboratory previously demonstrated the expression of secretin and its receptors in specific central neurons, and found for the first time that secretin is neuroactive in the cerebellum. We showed that bath application of secretin facilitated the release of GABA from terminals of basket...

Metabolism of copper 67 by the copper-deficient rat.

Role of Oxidative Stress in Ethanol-induced Neurotoxicity in the Developing Cerebellum

Objective(s) The purpose of this study was to investigate the role of oxidative stress in Purkinje cell neurotoxicity ofethanol-treated rat. Materials and Methods Male rat pups 4-day-old was used in this study. Ethanol was administered to rat pups at a dose of 6 g/kg from postnatal days (PDs) 4 to 5.  Pups were killed 90 min after the second alcohol treatment on PD 5 by decapitation and the ...